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KMID : 0525720160210010043
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Journal of Chitin and Chitosan
2016 Volume.21 No. 1 p.43 ~ p.50
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Development of Chitosan Based Natural Antibiotics for Diarrheal Treatment 2. Antimicrobial Effect of Organic iron Mixed Chitosan Oligosaccharide (Fe-OCHT) on Multidrug-Resistance Escherichia coli Isolates from Mares
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Noh Hye-Ji
Kim Hee-Kyong
Song Ha-Yeon
Kim Joon-Young
Kim Dae-Hyun
Cho Hyang-Hyun
Koh Hong-Bum
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Abstract
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A total 114 E. coli isolates from 73 samples during the period from 2012 to 2013 were obtained. Isolates were confirmed asbeing multidrug resistance (MDR) bacteria isolates showed resistance. Resistance to penicillins was found in penicillin (100%), ampicillin (88%), amoxicillin (89%), oxacillin (100%), ticarcillin (53%), aztreonam (52%), ticarcillin/clavulanic acid (56%) and imipenem (33%) of isolates. The blaTEM genes were detected in 100 (100%) of the 100 ampicillin-resistant isolates. We screened for antimicrobial effect of organic iron mixed chitosan oligosaccharide (Fe-OCHT, Product Name: EPECTROL-3) on multidrug-resistance isolates associated with multidrug resistance in E. coli from feces (73 samples) on mares. We evaluated the antimicrobial activity of organic iron mixed chitosan oligosaccharide against 3 multidrug-resistance E. coli which showed resistance over 15 different antibiotics. The chitosan oligosaccharide (OCHT) inhibited the growth of multidrug resistance E. coli isolates at a concentration of 1 μg/ml in 24 hours. Also, Fe-OCHT showed a significant antibacterial activity against multidrug resistance E. coli isolates at a concentration of 100 μg/ml in 5minutes. Fe-OCHT showed better antibacterial activity than the OCHT. Consequently, we confirmed that Fe-OCHT significantly inhibited multidrug resistance E. coli isolates and might be selected as a more effective natural antibiotics for diarrheal treatment.
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KEYWORD
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Chitosan oligosaccharide, Iron, , Ampicillin, E. coli, Antimicrobial activity
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